Regulation of sperm

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Sperm volume and its regulation may be crucial to natural fertility. In conclusion, inactivation of gelsolin during capacitation occurs by its binding to PIP 2 and tyrosine phosphorylation by SRC. The generation of lucigenin-dependent chemiluminesence could be divided into a mitochondrial component due to electron leakage at complexes 1 and 2 of the respiratory chain and a contribution from a putative plasma membrane NADPH oxidase that was inhibited by a cytosolic component Vernet et al. This is likely to be due to the dismutation of superoxide since a later paper demonstrated that rabbit sperm produce superoxide much of which is degraded by SOD Holland et al. ROS-dependent tyrosine phosphorylation was blocked by H89 whereas this inhibitor had no effect on tyrosine phosphorylation induced with the tyrosine phosphatase inhibitor vanadate Rivlin et al. In bovine sperm, binding to the oviductal epithelium is promoted by proteins that are secreted by the seminal vesicles and coat the heads of sperm by associating with plasma membrane phospholipids.
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For humans, the entire process of spermatogenesis is variously estimated as taking 74 days [6] [7] according to tritium-labelled biopsies and approximately days [8] according to DNA clock measurements. Journal of Molecular Histology. Too often the medical profile of a sperm donor is merely a snapshot of one day in the life of a healthy young man.
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